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TECHNOLOGY

DDS

Natural Spicules

Spicules, harvested from marine sponges, have a needle-like shape with a diameter of approximately 10–15 µm.
These natural, innovative materials are gaining attention for their benefits,
which include enhancing blood circulation, promoting collagen synthesis and cell division, providing anti-inflammatory and soothing effects, and softening the skin.

  • Inside the spicules, capillaries measuring
    0.5–1.5 µm run from end to end. ※ Used for loading active substances and
    oxygen delivery pathways
  • When magnified, the surface and cross-section of spicules reveal numerous pores ranging 10–40 µm, forming a skeletal structure. ※ Capable of delivering nano active ingredients

High-Purity Spicule Manufacturing Process

Innovative Non-chemical Methods For High-purity Spicule Manufacturing Process

Patented Purification Technology

We have developed advanced purification technologies for spicules tailored for skincare, earning patents for our innovations. Through non-chemical methods ensuring stability and high-purity processing techniques, the spicules harvested from sea beds can safely be incorporated into all types of cosmetics.

  • Source: Seabed
    Source: Seabed
  • Crushing
    Crushing
  • High-purity Process (10 Steps)
    High-purity Process (10 Steps)
  • High-purity Spicules
    High-purity Spicules
  • Spicule Collection
    Spicule Collection

Spicule Encapsulation and Coating Technology

  • Spicule + Active ingredients
    Spicule + Active ingredients
  • ULTRA-HIGH PRESSURE MOLDING
    ULTRA-HIGH PRESSURE MOLDING
  • Encapsulated & Coated
    Encapsulated & Coated
*1 Ultra-high pressure molding patent: 2022-514983 (Japan)

Neo spicule

A neo spicule is shaped like a hollow mesoporous silica rod, with substantial internal hollow spaces enabling the encapsulation of diverse active ingredients.
Its surface contains pores ranging from approximately 2 to 50nm, allowing for the encapsulation or release of active ingredients.

Neo Spicule Production Stages

Each neo spicule can encapsulate a variety of active ingredients within its internal space.
They can be produced with adjustable lengths to effectively penetrate the desired skin depth.

  • Silica Seed
    Silica Seed
  • ASR
    ASR(Asymmetric Silica Rod)
  • MSR
    MSR(Mesoporous Silica Rod)
  • HMSR (Neo Spicule)
    HMSR (Neo Spicule)(Hollow Mesoporous Silica Rod)

The next-generation “neo spicule”
can be manufactured to specific lengths suitable for various applications.

This enables precise delivery of active ingredients to targeted locations, making it versatile for use in cosmetics, pharmaceuticals, and medical devices.

Comparison of length between natural spicules and neo spicules

  • Natural spicules
    Natural spicules
  • Development of neo spicules in varying sizes (15–150㎛)
    Development of neo spicules in varying sizes (15–150㎛)

Advanced DDS Technology of Spicule Models

  • Mechanism of skin penetration
  • Painless penetration through size-controlled neo spicules
  • Versatile drug encapsulation/release capabilities
  • Controlled release timing

Applications

  • Medical Device
    1. Anti-aging fillers (Class 4)
    2. Fat-dissolving fillers (Class 4)
    3. Adhesive wound dressings for burn care (Class 2)
    4. Wound dressings for atopic dermatitis/psoriasis (Class 2)
    5. Wound dressings for scars and stretch marks (Class 2)
  • Medicinal Ingredients
    1. Dermatitis treatment
    2. Atopic dermatitis treatment
    3. Rheumatoid arthritis treatment
    4. Alopecia treatment
    5. Antimicrobial and antiviral agents
  • Cosmetics
    1. Anti-aging (functional)
    2. Hair loss improvement (functional)
    3. Acne improvement (functional)
    4. Atopic dermatitis improvement (functional)
    5. Skin barrier and elasticity enhancement